Mitochondrial glutamate carrier 2 (SLC25A18)

Mitochondrial glutamate carrier 2 (SLC25A18) is a mitochondrial inner membrane protein that transports L-glutamate into the mitochondrial matrix in symport with protons. This process is essential for glutamate metabolism in mitochondria, which contributes to ATP generation, ammonia detoxification, and prevention of neuronal excitotoxicity. SLC25A18 is part of the SLC25 family of mitochondrial carriers, which have a conserved structural fold and transport mechanism. Its function is especially relevant in the central nervous system, where it helps regulate neurochemical and metabolic processes. Altered expression or dysfunction of SLC25A18 has been linked to neurodegenerative diseases and white matter disorders, where it contributes to mitochondrial dysfunction, oxidative stress, and neuronal cell death.

Other names

Mitochondrial glutamate carrier 2GC2Glutamate/H(+) symporter 2Solute carrier family 25 member 18GC-2SLC25A18

Drugs (hypothetically) targeting SLC25A18 would modulate mitochondrial glutamate import or inhibit/protect against glutamate-induced excitotoxicity or mitochondrial dysfunction