Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10)

Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) is a small evolutionarily conserved protein that acts as a chaperone in the mitochondrial intermembrane space[3][4][5]. It is a core component of the TIM22 complex, which mediates the import and insertion of multi-pass transmembrane proteins, particularly metabolite carriers, into the inner mitochondrial membrane[1][3][4][5]. TIMM10 forms a heterooligomeric complex with other small Tim proteins (such as Tim9 and Tim12) and protects hydrophobic precursors from aggregation, ensuring their proper transfer and insertion. Dysfunction or mutation in TIMM10 impairs mitochondrial bioenergetics and can cause recessive disorders such as Mohr-Tranebjaerg syndrome, characterized by progressive neurodegeneration[3][5][7]. Key biological processes involving TIMM10 relate to mitochondrial integrity and metabolic competence, as it is indispensable for the assembly and maintenance of the mitochondrial inner membrane protein composition[1][3][5].

Other names

TIM10TIM10ATIMM10AMitochondrial import inner membrane translocase subunit Tim10 homologTranslocase of inner mitochondrial membrane 10Translocase of inner mitochondrial membrane 10 homolog (yeast)TIMM10 (yeast) homolog