Mitochondrial import inner membrane translocase subunit TIM16 (PAM16)

Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) is a 15.1 kDa protein component of the mitochondrial inner membrane that plays an essential role in the protein import machinery. It forms part of the presequence translocase-associated motor (PAM) complex, specifically acting as a co-chaperone with Pam18 (DNAJC19) to regulate the mitochondrial Hsp70-mediated ATP-driven import of proteins with N-terminal targeting sequences across the inner mitochondrial membrane. TIM16 has a conserved J-like domain but lacks the HPD active motif found in true J-proteins. It stabilizes the active conformation of PAM18 and modulates the activity of the import motor. Mutations in this protein are associated with severe mitochondrial dysfunction, including some forms of skeletal dysplasia, and its dysregulation has been reported in several cancer types. PAM16 is essential for mitochondrial biogenesis and cellular energy metabolism; thus, it is not currently considered a druggable therapeutic target, but it is of high significance in basic mitochondrial biology and disease pathogenesis[1][2][3][4].

Other names

PAM16MAGMASTIM16TIMM16CGI-136SMDMDMmitochondria-associated granulocyte macrophage CSF-signaling moleculeMagmaspresequence translocase-associated motor 16 homologmitochondrial import inner membrane translocase subunit TIM16magmas-like proteinmitochondria associated protein involved in granulocyte macrophage colony stimulating factor signal transductionpresequence translocated-associated motor subunit PAM16