Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)

Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) is a protein encoded by the human TIMM17A gene. It is an integral membrane protein of the inner mitochondrial membrane and is an essential component of the TIM23 complex that facilitates the translocation of nucleus-encoded and presequence-containing mitochondrial proteins from the cytosol into the mitochondrial matrix. TIMM17A forms the core of the TIM23 complex along with Tim23 and Tim21, creating a channel for protein translocation, and interacts with Tim44 and mitochondrial Hsp70 for further import and sorting[1][2][3][4][5]. TIMM17A is found in all eukaryotes and is highly conserved across species, underscoring its ancient and fundamental role in mitochondrial biogenesis and function. Mutations or dysfunction in this component would disrupt mitochondrial protein import and thereby compromise cellular energy metabolism, but there is no evidence currently linking TIMM17A to specific human disease phenotypes or identifying it as a direct druggable target[3][5][7].

Other names

Tim17-ATIMM17AMIMT17TIM17TIMM17Inner membrane preprotein translocase Tim17amitochondrial import inner membrane translocase subunit Tim17-Ainner membrane preprotein translocase Tim17amitochondrial inner membrane translocasepreprotein translocasetranslocase of inner mitochondrial membrane 17 homolog ATIMM17A[2][7]

None known. Not a primary drug target[7].