Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)

Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) is a core component of the TIM23 complex in the inner mitochondrial membrane, essential for translocation of proteins from the cytosol into the mitochondrial matrix or for sorting them into the inner membrane[1][2][3][5]. TIMM17B, together with other subunits such as Tim23 and Tim21, forms a dynamic structure involved in recognizing protein presequences and facilitating their import in a membrane potential-dependent fashion[1][3]. TIMM17B contains four transmembrane domains forming a lateral cavity crucial for presequence protein translocation, with conserved negative charges near the intermembrane space that mediate these interactions[1]. While not a classic drug target, TIMM17B's function is fundamental for mitochondrial health and overall cellular metabolism[1][2][3]. If additional information is required for clinical or drug development contexts (such as disease associations), more specific protein variants (such as human TIMM17A/TIMM17B) and pathological models would need to be referenced. Currently, there are no approved drugs or direct clinical assays based on TIMM17B[2][5].

Other names

TIMM17BTim17-BTim17BJM3DXS9822translocase of inner mitochondrial membrane 17 homolog Binner mitochondrial membrane preprotein translocase