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Mitochondrial import inner membrane translocase subunit Tim21 (TIMM21)
- Target
- TIMM21
- Molecular classification
- Other (subunit of mitochondrial translocase complex; not a receptor, enzyme, channel, or classic transporter)
01
Overview
Mitochondrial import inner membrane translocase subunit Tim21 (TIMM21) is a mitochondrial inner membrane protein that is part of the TIM23 complex, which is essential for translocation of transit peptide-containing proteins across the mitochondrial inner membrane and for the assembly of mitochondrial respiratory chain complexes. It is required for the integration of presequence-containing subunits into respiratory-chain intermediates but is not essential for general protein import into mitochondria. TIMM21 is not a receptor, enzyme, or transporter in the classical pharmacological sense, and is not currently considered a direct therapeutic target[1][2][4][5][6].
- Other names
- TIM21C18orf55HSPC154TIM21-like proteintranslocase of inner mitochondrial membrane 21 homolog
02
Biological functions
Mitochondrial protein importAssembly of respiratory chain complexes
03
Disease associations
Other (Currently no strong evidence for a direct role in cancer, neurodegeneration, or major human diseases)
04
Safety considerations
Defects could affect mitochondrial protein import or respiratory chain assembly but no approved drugs or therapies targeting TIMM21, and no major safety data
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