Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)

Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) is a nuclear-encoded mitochondrial intermembrane space chaperone protein that is highly conserved and shares similarity with yeast Tim proteins[1][4][7]. TIMM8B forms complexes to facilitate the import and insertion of multi-pass transmembrane proteins and participate in protein trafficking across the mitochondrial inner membrane before their integration into the membrane[1][2][4]. It also functions as an auxiliary assembly factor important for the formation and stability of cytochrome c oxidase (Complex IV) in the mitochondrial respiratory chain[2]. Disease associations include Mohr-Tranebjaerg Syndrome and dystonia, as well as possible links to hereditary paraganglioma due to proximity to the SDHD gene[1][7]. There is currently no evidence that TIMM8B is a direct therapeutic drug target, nor are there approved drugs known to interact with this protein. Its function is primarily as a component of the mitochondrial import machinery, crucial for mitochondrial protein biogenesis and respiratory chain function[2][4][9].

Other names

DDP2DDPLFLJ21744MGC102866MGC117373DDP-like proteinDeafness dystonia protein 2Tim8 B