Target intelligence / Profile preview

Mitochondrial Malate Dehydrogenase (mMDH)

Target: mMDH
Molecular classification: Enzyme, Dehydrogenase

Overview

Mitochondrial malate dehydrogenase (MDH) is a critical enzyme found in the mitochondria of eukaryotic cells. This enzyme plays essential roles in cellular metabolism, particularly in the tricarboxylic acid (TCA) cycle and the malate-aspartate shuttle. It catalyzes the reversible NAD+/NADH-dependent interconversion between malate and oxaloacetate.

Biological functions

Tricarboxylic acid (TCA) cycleMalate-aspartate shuttleOxidation-reductionCellular metabolism

Disease associations

Various pathological conditions

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