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Mitochondrial matrix import factor 23 (MIX23)
- Target
- MIX23
- Molecular classification
- Other (Mitochondrial protein import regulator), Protein coding gene, Coiled-coil domain-containing protein
01
Overview
Mitochondrial matrix import factor 23 (MIX23), also known as coiled-coil domain-containing protein 58 (CCDC58), is a mitochondrial intermembrane space protein critical for efficient protein import into the mitochondrial matrix, especially when the usual function of translocase of the inner membrane 23 (TIM23) is compromised[1][4]. MIX23 is upregulated under mitochondrial protein import stress, regulated by the transcription factor Rpn4, and is evolutionarily conserved across species[1]. It participates as a stabilizer and regulator of the mitochondrial protein import machinery and is not currently linked to specific diseases or known drug interactions[1][2][4].
- Other names
- MIX23CCDC58FLJ33273Coiled-coil domain-containing protein 58protein MIX23
02
Mechanism of action
None known; no drugs attributed to this target
03
Biological functions
Protein import into mitochondrial matrixRegulation of mitochondrial proteostasisStress response to mitochondrial protein import defects
04
Disease associations
Other (no specific disease role reported in literature or biomedical databases)
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