Mitochondrial Membrane Potential-Dependent Cellular Uptake

Mitochondrial membrane potential-dependent cellular uptake refers to the process by which molecules, ions, or probes are selectively transported into mitochondria based on the electrochemical gradient (membrane potential) across the mitochondrial inner membrane. This membrane potential (ΔΨm) is a critical component of mitochondrial function and is generated by proton pumps during oxidative phosphorylation. It plays a vital role in ATP production, calcium homeostasis, ROS regulation, and is exploited experimentally for drug delivery and assessing mitochondrial health.

Other names

ΔΨm-dependent cellular uptakeMitochondrial membrane potential driven importElectrochemical gradient-mediated mitochondrial entry

Driven by electrochemical gradient (ΔΨm); selective import/export of molecules into mitochondria. Cationic compounds cross membranes more readily when ΔΨm is high; collapse or depolarization reduces uptake efficiency.