Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (SLC25A51)

Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (SLC25A51) is a member of the mitochondrial carrier (solute carrier family 25) responsible for importing NAD+ into the mitochondrial matrix, a process vital for maintaining mitochondrial respiration and cellular energy production[1][2][3]. Loss of SLC25A51 leads to depletion of mitochondrial NAD+, impaired respiration, and disruption of bioenergetic homeostasis, while overexpression restores mitochondrial function[1][3]. SLC25A51 is conserved across eukaryotes and is the functional ortholog of yeast NDT1, essential for ensuring sufficient NAD+ for metabolic pathways including the TCA cycle and electron transport chain[2][3][4]. Molecular studies reveal a transport mechanism involving specific lipid interactions and a ligand-induced gating process controlling NAD+ import[4]. No therapeutically approved drugs are currently known to target SLC25A51 directly, but its essential role in mitochondrial metabolism positions it as a candidate target for studying mitochondrial function and metabolic disease intervention[1][2][3].

Other names

MCART1Mitochondrial carrier triple repeat protein 1SLC25A51MGC14836CG7943mitochondrial NAD+ transportermitochondrial NAD(+) transporter SLC25A51mitochondrial carrier triple repeat 1mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51mitochondrial NAD+ transporter SLC25A51

NAD+ transport across the inner mitochondrial membrane