Mitochondrial nucleoid-associated protein 1 (MTNAP1)

Mitochondrial nucleoid-associated protein 1 (MTNAP1) is a nuclear-encoded, mitochondrial membrane-associated protein predicted to play a critical role in controlling mitochondrial DNA copy number and replication. It binds double-stranded DNA throughout the mitochondrial genome without sequence specificity and promotes mtDNA replication, thereby influencing mitochondrial metabolism and cell proliferation. MTNAP1 is associated with the mitochondrial nucleoid and does not act as a receptor, enzyme, or transporter. Pathogenic variants in MTNAP1 have genetic associations with postpoliomyelitis syndrome and developmental and epileptic encephalopathy 28 in humans. Its wider biological and pathological significance, as implied by some aliases, is not confirmed by credible scientific databases. There are no drugs, mechanisms of action, biomarkers, or recognized safety considerations documented for MTNAP1.

Other names

C17orf80MIG3HLC8HLC-8FLJ20721SPEP1Cell migration-inducing gene 3 proteinHuman lung cancer oncogene 8 proteinProtein C17orf80Sperm-expressed protein 1Migration-inducing protein 3Lung cancer-related protein 8Uncharacterized protein C17orf80

Not applicable, as no known drugs specifically target this molecule