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Mitochondrial Open Reading Frame of the 12S rRNA Type-c (MOTS-c)
- Target
- MOTS-c
- Molecular classification
- Peptide, Mitochondrial-derived peptide
01
Overview
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the MT-RNR1 gene. It plays a role in metabolic regulation by activating AMPK and regulating nuclear gene expression upon metabolic stress. It has implications for treating diabetes, obesity, and age-related diseases. It translocates to the nucleus to interact with transcription factors like NRF2/NFE2L2.
02
Mechanism of action
Inhibits folate cycle, activates AMPK, regulates nuclear gene expression (e.g., NRF2/NFE2L2 pathway)
03
Biological functions
Metabolic regulationAMPK activationRegulation of nuclear gene expressionInsulin sensitivity enhancementGlucose uptake stimulationFatty acid oxidationAntioxidant response regulation
04
Disease associations
Diabetes mellitusObesityAgingCardiovascular diseaseOsteoporosisMetabolic syndrome
05
Safety considerations
Delivery methods for exogenous peptide therapy need further research.Long-term effects of MOTS-c administration are not fully understood.
06
Biomarkers
Serum/plasma MOTS-c levels (potential biomarker for aging, metabolic disease)
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