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Target intelligence / Profile preview
Mitochondrial Oxidative Phosphorylation Pathway (OXPHOS)
- Target
- OXPHOS
- Molecular classification
- Enzyme complex, Metabolic pathway
01
Overview
The mitochondrial oxidative phosphorylation (OXPHOS) pathway is the primary metabolic process by which eukaryotic cells generate ATP. It involves a series of protein complexes in the inner mitochondrial membrane that transfer electrons to molecular oxygen, coupling this to ATP synthesis. Dysfunction in OXPHOS is implicated in numerous diseases.
- Other names
- Electron Transport ChainRespiratory ChainOxidative Phosphorylation
02
Mechanism of action
Inhibition of electron transport chain complexes; uncoupling of proton gradient
03
Biological functions
ATP synthesisElectron transportProton gradient generationCellular respirationRedox balance
04
Disease associations
Neurodegenerative disordersMetabolic syndromesAging-related conditionsCancerMitochondrial diseases
05
Safety considerations
Reactive oxygen species productionMitochondrial toxicityDrug-induced mitochondrial dysfunction
06
Interacting drugs
Rotenone
6 more in the full profile.
07
Biomarkers
ATP levelsROS productionMitochondrial DNA mutationsExpression levels of OXPHOS subunits
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