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Mitochondrial Pyruvate Carrier 1 (MPC1)
- Target
- MPC1
- Molecular classification
- Transporter, Mitochondrial Carrier
01
Overview
Mitochondrial pyruvate carrier 1 (MPC1) is a protein that forms part of the mitochondrial pyruvate carrier complex. This complex is located in the inner mitochondrial membrane and facilitates the transport of pyruvate from the cytosol into the mitochondria. This process is essential for linking glycolysis to oxidative metabolism via the tricarboxylic acid (TCA) cycle. MPC1 is a therapeutic target for metabolic diseases and cancer.
- Other names
- BRP44LMPYCDdJ68L15.3CGI-129SLC54A1
02
Mechanism of action
Modulation of pyruvate transport into mitochondria, impacting glycolysis and oxidative phosphorylation.
03
Biological functions
Pyruvate transportGlucose energy metabolismPyruvate metabolismTCA cycle activityRespiratory electron transportATP synthesis
04
Disease associations
Mitochondrial pyruvate carrier deficiency (MPYCD)Lactic acidosisMetabolic disordersCancerDiabetes mellitus type IINon-alcoholic fatty liver disease (NAFLD)Neurodegenerative disorders
05
Safety considerations
Potential for lactic acidosis if inhibited excessively.Metabolic imbalances
06
Biomarkers
Blood lactate levelsBlood pyruvate levels
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