Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitochondrial Respiratory Chain Complex II (SDH)
- Target
- SDH
- Molecular classification
- Enzyme, Oxidoreductase, Mitochondrial protein, Respiratory chain complex
01
Overview
Mitochondrial respiratory chain complex II, also known as succinate dehydrogenase (SDH), is a crucial enzyme complex located in the inner mitochondrial membrane. It serves as a key link between the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC), playing an essential role in cellular energy metabolism. It is composed of four subunits: SDHA, SDHB, SDHC, and SDHD. Complex II catalyzes the oxidation of succinate to fumarate in the TCA cycle and the transfer of electrons from FADH2 to ubiquinone within the ETC, contributing to ATP production via oxidative phosphorylation. Mutations or dysfunctions in any subunit can lead to severe human diseases, including neurodegenerative disorders and various cancers.
- Other names
- Succinate dehydrogenaseComplex II
02
Mechanism of action
Inhibition of succinate dehydrogenase activity
03
Biological functions
Electron transportOxidative phosphorylationATP synthesisSuccinate oxidationUbiquinone reductionTricarboxylic acid cycle
04
Disease associations
Neurodegenerative diseaseCancerLeigh syndromeOptic atrophyInflammation-linked pathologiesMetabolic disorders
05
Safety considerations
Potential for off-target effects on mitochondrial functionDevelopment of resistanceImpact on cellular metabolism
06
Biomarkers
SDHA mutationsSDHB mutationsSDHC mutationsSDHD mutations
Beyond the preview
Go deeper on Mitochondrial Respiratory Chain Complex II (SDH).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitochondrial Respiratory Chain Complex II (SDH).