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Mitochondrial Respiratory Complex I
- Molecular classification
- Enzyme, Protein Complex
01
Overview
Mitochondrial Respiratory Complex I, also known as NADH:ubiquinone oxidoreductase, is the first and largest enzyme of the mitochondrial electron transport chain. It catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q), coupled with proton translocation across the inner mitochondrial membrane. Dysfunction is linked to various hereditary and degenerative diseases due to impaired oxidative phosphorylation or increased reactive oxygen species (ROS) generation.
- Other names
- Protein complex 1NADH:ubiquinone oxidoreductaseComplex I
02
Mechanism of action
Inhibition of electron transfer, disruption of proton gradient
03
Biological functions
Electron transportProton transportOxidative phosphorylationEnergy production
04
Disease associations
Neurodegenerative diseaseHereditary disordersMitochondrial dysfunction
05
Safety considerations
Increased ROS generationImpaired oxidative phosphorylation
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