Mitochondrial ribosomal protein L11 (MRPL11)

Mitochondrial ribosomal protein L11 (MRPL11) is a protein encoded by the nuclear MRPL11 gene and is a component of the 39S large subunit of the mitochondrial ribosome[1][3]. It plays a structural and functional role in mitochondrial protein synthesis, being involved in the assembly of the mitochondrial ribosome and translation of mitochondrial-encoded proteins critical for energy production and oxidative phosphorylation[2][3]. Although mutations in MRPL11 have been associated with certain mitochondrial diseases, including dyskinetic cerebral palsy and combined oxidative phosphorylation deficiency 7[1][4], it is not categorized as a classic druggable therapeutic target such as receptors, enzymes, transporters, or ion channels. The protein’s biological functions are specific to the maintenance and expression of the mitochondrial genome through protein synthesis within mitochondria[2]. Key contextual note: MRPL11 is not recognized as a direct therapeutic target and there are no drugs or mechanisms of action currently described for modulating its function for clinical use[1][3]. It is primarily of interest in genetic and mitochondrial disease research.

Other names

Large ribosomal subunit protein uL11mCGI-113L11mtMRP-L11uL11m39S ribosomal protein L11 (mitochondrial)mitochondrial large ribosomal subunit protein uL11mL11MT