Mitochondrial ribosomal protein L18 pseudogene (null)

The mitochondrial ribosomal protein L18 pseudogene (ENSG00000262636) is a non-functional genomic sequence related to the MRPL18 gene. MRPL18 encodes a protein component of the 39S large subunit of the mitochondrial ribosome, involved in protein synthesis within mitochondria[1][5]. However, **pseudogenes such as ENSG00000262636 do not produce a functional protein product**, resulting from historical gene duplications or retrotranspositions and subsequently acquiring disabling mutations[2][3][7]. While the parent gene is essential for mitochondrial translation, pseudogenes are generally considered “genomic fossils” with no direct biological or clinical activity[2][7][8]. This target does not represent a receptor, enzyme, transporter, or any molecule class of therapeutic interest; **it is an annotation artifact**, and there is no evidence or recognized context in which this specific pseudogene is therapeutically actionable, biologically functional, or clinically relevant[2][7].

Other names

MRPL18 pseudogeneribosomal protein L18 pseudogeneMRPL18P

null