Mitochondrial ribosomal protein L27 (MRPL27)

Mitochondrial ribosomal protein L27 (MRPL27) is a nuclear-encoded protein that forms part of the 39S large subunit of the mammalian mitochondrial ribosome (mitoribosome)[1][2][3]. It plays an essential role in mitochondrial protein synthesis, specifically within the processes of translation elongation, electron transport, and ATP production. MRPL27 is localized to the inner mitochondrial membrane, contributing to the structure and function of the mitoribosome, which is responsible for synthesizing proteins critical for oxidative phosphorylation[1][2][3]. Structurally, L27 is positioned near the peptidyl transferase center and interacts with mitochondrial-specific factors and other ribosomal proteins to facilitate mitochondrial translation[2]. Aberrant overexpression of MRPL27 is associated with poorer prognosis in cholangiocarcinoma, making it both a potential prognostic biomarker and a candidate therapeutic target in oncology[1]. Currently, there are no known drugs or direct inhibitors/ligands of MRPL27 described in the literature or clinical use[1].

Other names

Large ribosomal subunit protein bL27mL27mtHSPC250MRP-L27bL27m39S ribosomal protein L27, mitochondrialmitochondrial large ribosomal subunit protein bL27m