Mitochondrial ribosomal protein L39 (MRPL39)

Mitochondrial ribosomal protein L39 (MRPL39) is a nuclear gene-encoded protein that forms part of the large 39S subunit of the mitochondrial ribosome (mitoribosome), which is responsible for protein synthesis within the mitochondria[1][3][5][9]. MRPL39 is essential for the translation of mitochondrial genome-encoded proteins required for oxidative phosphorylation and cellular energy production[3][5][10]. Deficiency or biallelic variants in the MRPL39 gene cause impaired mitochondrial translation, leading to conditions such as combined oxidative phosphorylation deficiency 59 and other mitochondrial diseases presenting with multisystem symptoms[5][12]. MRPL39 is not currently considered a direct therapeutic target, receptor, or typical drug target class[5][12].

Other names

C21orf92COXPD59L39mtL5mtMRP-L5MRPL5MSTP003PRED22PRED66RPML5mL39FLJ20451MGC104174MGC3400ORF22C21orf8