Mitochondrial ribosomal protein L47 (MRPL47)

Mitochondrial ribosomal protein L47 (MRPL47) is a nuclear-encoded protein that integrates into the large (39S) subunit of the mammalian mitochondrial ribosome (mitoribosome)[1]. It plays a critical role in the synthesis of mitochondrial proteins, which are essential for the oxidative phosphorylation (OXPHOS) pathway and energy production in mitochondria[1][2][3]. MRPL47 has evolved divergently compared to its bacterial homolog RPL29 and is unique to eukaryotes[3]. Unlike bacterial ribosomes, mammalian mitoribosomes have a higher protein-to-rRNA ratio and a distinct structural organization, with many proteins, including MRPL47, serving to compensate for reduced rRNA content and to facilitate the assembly, stabilization, and functionality of the ribosome[1][3]. MRPL47 is not implicated in receptor, transporter, or enzyme activity and is primarily a structural protein. While mitochondrial ribosomal proteins broadly participate in cellular metabolism and have emerging links to diseases, MRPL47 itself is not described as a direct therapeutic target, biomarker, or drug target in currently available literature[1][2][3].

Other names

MRPL47