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Mitochondrial ribosomal protein S12 (MRPS12)
- Target
- MRPS12
- Molecular classification
- Ribosomal protein, Mitochondrial ribosomal protein, Structural protein (component of small mitoribosomal subunit), Other
01
Overview
Mitochondrial ribosomal protein S12 (MRPS12) is a nuclear-encoded component of the small (28S) subunit of the mitochondrial ribosome, essential for the fidelity of mitochondrial protein synthesis and involved in decoding mitochondrial mRNA. MRPS12 is implicated in controlling susceptibility to aminoglycoside antibiotics and has been associated with cancer biology, including acting as a potential oncogene and prognostic biomarker in ovarian cancer. Recent analyses reveal that its overexpression correlates with poor outcomes and immune cell infiltration in ovarian cancer. MRPS12 is critical for mitochondrial function and, by extension, cellular energy production, with broader links to disease when dysregulated.
- Other names
- 28S ribosomal protein S12, mitochondrialSmall ribosomal subunit protein uS12mMRP-S12S12mtRPS12RPSM12uS12mMT-RPS12
02
Mechanism of action
Aminoglycosides disrupt decoding fidelity by binding near MRPS12 in the mitoribosome
03
Biological functions
Protein synthesis within mitochondrionComponent of mitochondrial translation machineryDecoding fidelity during mitochondrial translationRegulation of susceptibility to aminoglycoside antibioticsPossible roles in cell cycle signaling (e.g., G2/M checkpoint, PI3K/AKT/mTOR, p53 pathway)Other
04
Disease associations
Cancer (notably ovarian cancer)Possible role in hereditary deafness (DFNA4)Other (mechanistic connections to neurodegeneration and impaired mitochondrial function demonstrated for multiple mitochondrial ribosomal proteins)
05
Safety considerations
Mitochondrial translation inhibition may induce cell death or mitochondrial dysfunctionAminoglycoside antibiotics can induce mitochondrial toxicity, especially with mutations in MRPS12Potential for ototoxicity (deafness) due to gene interactions
06
Interacting drugs
Aminoglycoside antibiotics (affect decoding fidelity; not a therapeutic inhibitor, but a chemical interaction)
07
Biomarkers
Prognostic biomarker in ovarian cancer (higher MRPS12 expression correlates with worse survival and higher macrophage/neutrophil infiltration in OC)
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