Mitochondrial ribosomal protein S18A (MRPS18A)

Mitochondrial ribosomal protein S18A (MRPS18A) is a nuclear-encoded protein that is a structural constituent of the small 28S subunit of the mitochondrial ribosome in humans. It is involved in mitochondrial protein synthesis, critical for the translation of proteins encoded by mitochondrial DNA. This protein is a member of the ribosomal protein S18P family and shows sequence similarity to bacterial S18 proteins, though substantial sequence divergence is seen across species. MRPS18A is not a known pharmacological or therapeutic target, and there are no drugs with a described mechanism of action involving it. Genetic variants have been associated with disorders such as Fallopian tube adenocarcinoma and Leigh disease, but its role is not as a primary disease driver or drug target[1][3][5][6][8].

Other names

MRPS18-3mL6639S ribosomal protein S18-3, mitochondrial39S ribosomal protein S18a, mitochondrialLarge ribosomal subunit protein bS18aLarge ribosomal subunit protein mL66MRP-S18-3MRP-S18-aS18mt-aFLJ10548Mitochondrial ribosomal protein S18-3HumanS18bMrps18aS18bmt28S ribosomal protein S18-3, mitochondrial28S ribosomal protein S18a, mitochondrialMitochondrial large ribosomal subunit protein bS18m-AMitochondrial large ribosomal subunit protein bS18aMitochondrial large ribosomal subunit protein mL66