Mitochondrial ribosomal protein S18B (MRPS18B)

Mitochondrial ribosomal protein S18B (MRPS18B) is a nuclear-encoded protein that is a component of the small (28S) subunit of the mitochondrial ribosome, where it serves as a structural constituent essential for mitochondrial protein synthesis. Unlike prokaryotic ribosomes, mammalian mitoribosomes have a higher protein-to-rRNA ratio and lack certain rRNA species, such as 5S rRNA. MRPS18B is a member of the ribosomal protein S18P family and one of three human mitochondrial S18-like proteins, each with significant sequence divergence. The gene is located on chromosome 6 and is essential for translation within mitochondria, thereby impacting mitochondrial function and cellular energy production. Variants in MRPS18B have been associated with rare diseases like Leigh disease and megaesophagus but it has no established role as a direct therapeutic target or biomarker[1][2][3][10][11].

Other names

C6orf14HSPC183MRP-S18-2MRPS18-2PTD017mS4028S ribosomal protein S18-2, mitochondrial28S ribosomal protein S18b, mitochondrialSmall ribosomal subunit protein bS18bSmall ribosomal subunit protein mS40S18amtHumanS18amitochondrial ribosomal protein S18B