Mitochondrial ribosomal protein S23 (MRPS23)

Mitochondrial ribosomal protein S23 (MRPS23) is a structural component of the small 28S subunit of the mammalian mitochondrial ribosome. Encoded by a nuclear gene, it is imported into mitochondria and is important for mitochondrial protein synthesis, supporting the oxidative phosphorylation that provides most cellular energy. MRPS23 has been implicated in the pathogenesis of several diseases: its overexpression and post-translational modifications enhance proliferation and metastatic potential in breast cancer and glioma, while pathogenic variants cause clinical mitochondrial disorders with defects in oxidative phosphorylation and energy metabolism. MRPS23 has also been proposed as a cancer biomarker and a potential—but currently untargeted—therapeutic target[1][3][6].

Other names

HSPC329CGI-138MRP-S23S23mtmS2328S ribosomal protein S23, mitochondrialCOXPD46mitochondrial small ribosomal subunit protein mS23

Not well established; would depend on drug and context. (Drugs have not been specifically identified that target MRPS23 directly in the literature reviewed[1][3].)