Mitochondrial ribosomal protein S31 pseudogene 5 (MRPS31P5)

Mitochondrial ribosomal protein S31 pseudogene 5 (MRPS31P5) is currently annotated as a pseudogene related to the mitochondrial ribosomal protein S31 gene. However, recent research suggests that MRPS31P5 is not a true pseudogene, but rather a functional descendent of a chimeric RNA formed by HNRNPA1L2 and SUGT1 (H-S chimera)[2]. Compared to its supposed parent gene MRPS31, MRPS31P5 shares higher sequence and functional similarity to the chimeric H-S RNA[2]. Functional studies indicate that silencing MRPS31P5 in human cells induces cell cycle arrest and apoptosis, suggesting a role in regulating cell proliferation and viability[2]. Despite its functional effects in cell models, there is no evidence that MRPS31P5 encodes a protein or acts as a direct therapeutic target (such as a receptor, enzyme, transporter, or transcription factor)[1][2][4]. No drugs are known to target MRPS31P5, and it is not currently recognized as a biomarker or as being involved in specific diseases. MRPS31P5 is likely misannotated as a pseudogene of MRPS31 due to sequence similarity, but it functions more as a non-coding RNA derived from a gene fusion event[2]. Older literature and some databases may refer to it by alternative names or as a processed mitochondrial ribosomal protein pseudogene[1][4]. There is no protein product or classified 'target' activity, and it is not druggable by current standards. In summary, MRPS31P5 is not considered a therapeutic target, and its annotation as a pseudogene is likely technically incorrect based on current literature[2]. It is more accurately described as a non-coding functional RNA arising from genome rearrangement and chimeric RNA evolution[2].

Other names

MRPS31P5MRPS31P3Mitochondrial ribosomal protein S31 pseudogene 3

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