Mitochondrial ribosomal protein S35 pseudogene 3 (MRPS35P3)

Mitochondrial ribosomal protein S35 pseudogene 3 (MRPS35P3) is a processed pseudogene in the human genome. Pseudogenes are DNA sequences similar to known genes but generally non-functional due to mutations or lack of regulatory elements necessary for gene expression. MRPS35P3 does not encode a functional protein and is not considered a therapeutic target. It is related by sequence to the functional mitochondrial ribosomal protein S35 (MRPS35), which participates in mitochondrial protein synthesis as part of the mitochondrial small ribosomal 28S subunit, but MRPS35P3 itself does not have an established biological or disease role[2][4][9]. MRPS35P3 can be referred to in databases such as NCBI Gene: 359779, Ensembl: ENSG00000270192, and HGNC: 29770[9]. The functional MRPS35 gene (not the pseudogene) encodes a protein important for mitochondrial protein synthesis and has roles in mitochondrial translation pathways[5]. Pseudogenes like MRPS35P3 generally do not code for proteins and do not have established functions in drug interactions, biomarkers, safety concerns, or use as therapeutic targets[2][4][9]. Summary: MRPS35P3 is a non-coding pseudogene, not a real drug target or functional protein. It is not used in therapeutics, and there is nothing indicating biological or clinical relevance as a target. The entry name is correct for a pseudogene, but this type of entry should not be considered a therapeutic or pathway target in structured pharmacological databases[2][4][9].

Other names

MRPS35P3mitochondrial ribosomal protein S35 pseudogene 3