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Target intelligence / Profile preview
Mitochondrial ribosomal protein S9 (MRPS9)
- Target
- MRPS9
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Other
01
Overview
Mitochondrial ribosomal protein S9 (MRPS9) is a protein encoded by the nuclear MRPS9 gene and is a structural component of the small 28S subunit of the mitochondrial ribosome (mitoribosome) in mammals. These ribosomal proteins facilitate protein synthesis within mitochondria. Unlike cytoplasmic ribosomes, mitochondrial ribosomes have a higher protein-to-rRNA ratio and differ notably in their biochemical composition and sequence across species. MRPS9 is necessary for mitochondrial translation, but is not recognized as a druggable target or disease-associated protein in most current research.
- Other names
- MRP-S9RPMS9S9mtuS9m28S ribosomal protein S9, mitochondrialSmall ribosomal subunit protein uS9m
02
Mechanism of action
None known.
03
Biological functions
Structural constituent of mitochondrial ribosomeMitochondrial translationProtein synthesis within mitochondriaRNA binding
04
Disease associations
Limited evidence; not directly implicated as a primary causative factor or therapeutic target in any particular disease.Some genetic associations reported: "Leopard Syndrome 1" and "Megalencephalic Leukoencephalopathy With Subcortical Cysts 1" are listed as associated conditions, but not as primary drivers or direct targetsOther (not a canonical drug target for known therapeutic indications.)
05
Safety considerations
None described
06
Interacting drugs
None known
07
Biomarkers
None established
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