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Mitochondrial Ribosome (Human) (mitoribosome)
- Target
- mitoribosome
- Molecular classification
- Ribonucleoprotein, Ribosome
01
Overview
The human mitochondrial ribosome, or mitoribosome, is a ribonucleoprotein complex located within mitochondria. It synthesizes proteins encoded by mtDNA, which are essential for oxidative phosphorylation and ATP production. It is composed of a 28S small subunit and a 39S large subunit, forming a 55S complex. The mitoribosome contains three rRNA molecules and approximately 80 proteins, with about 36 being mitochondria-specific. Mutations affecting mitoribosomal RNA genes or nuclear genes encoding its protein components can lead to severe mitochondrial diseases.
- Other names
- Human mitoribosomeMitochondrial ribosomemt-ribosome55S mitoribosome
02
Biological functions
Protein synthesis (mitochondrial)Oxidative phosphorylationATP production
03
Disease associations
Mitochondrial diseaseMetabolic disorders
04
Safety considerations
Off-target effects on cytoplasmic ribosomesMitochondrial toxicity
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