Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitochondrial RNA Polymerase (POLRMT)
- Target
- POLRMT
- Molecular classification
- Enzyme, RNA Polymerase, Transcription factor
01
Overview
Mitochondrial RNA polymerase (POLRMT) is a nuclear-encoded enzyme responsible for transcribing mitochondrial DNA (mtDNA) into RNA. This process is essential for the expression of mitochondrial genes and the production of RNA primers required for mtDNA replication. POLRMT is a single-subunit, DNA-dependent RNA polymerase that shares significant sequence and structural homology with bacteriophage T7 RNA polymerase. It requires TFAM and TFB2M for initiation, and TEFM for elongation. POLRMT is a potential therapeutic target especially relevant to cancer cells reliant on high oxidative phosphorylation rates. Inhibiting this enzyme could selectively impact rapidly dividing cells. Additionally, some antiviral ribonucleoside analogs have off-target inhibitory effects on POLRMT activity.
- Other names
- APOLMTMTRNAPMTRPOLh-mtRPOL
02
Mechanism of action
Inhibition of mitochondrial RNA synthesis
03
Biological functions
TranscriptionmtDNA replicationGene expressionPrimer synthesis
04
Disease associations
Combined Oxidative Phosphorylation Deficiency 55Mitochondrial DNA Depletion Syndrome type 2
05
Safety considerations
Off-target effects of antiviral drugsPotential for mitochondrial toxicitySelectivity between mitochondrial and nuclear RNA polymerases
06
Interacting drugs
Antiviral ribonucleoside analogs (e.g., for Hepatitis C virus)
1 more in the full profile.
Beyond the preview
Go deeper on Mitochondrial RNA Polymerase (POLRMT).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitochondrial RNA Polymerase (POLRMT).