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Target intelligence / Profile preview
Mitochondrial Transcription Factor A (TFAM)
- Target
- TFAM
- Molecular classification
- Transcription factor, High-mobility group (HMG) box protein
01
Overview
Mitochondrial transcription factor A (TFAM) is a key protein encoded by the nuclear TFAM gene. It is an essential component of mitochondrial nucleoids and plays a central role in the maintenance, transcription, and replication of mitochondrial DNA (mtDNA). Altered levels or function of TFAM are linked with neurodegenerative diseases and mutations can lead directly to syndromes involving defective oxidative phosphorylation.
- Other names
- mtTFA
02
Mechanism of action
N/A
03
Biological functions
DNA bindingTranscription activationGenome packagingReplication supportMitochondrial gene expressionmtDNA maintenance
04
Disease associations
Neurodegenerative diseaseKearns–Sayre syndromeAlzheimer's diseaseParkinson's diseaseHuntington's diseaseDefective oxidative phosphorylation
05
Safety considerations
Altered levels linked with diseaseMutations lead to defective oxidative phosphorylation
06
Biomarkers
TFAM levels in neurodegenerative diseasesmtDNA copy number
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