Mitochondrial transcription termination factor 2 (MTERF2)

Mitochondrial transcription termination factor 2 (MTERF2) is a nuclear-encoded mitochondrial protein that binds to mitochondrial DNA and plays a regulatory role in the transcription of mitochondrial mRNA and rRNA species. It possesses DNA-binding activity and is primarily located in the mitochondrion. MTERF2 is relatively abundant within mitochondria and is thought to regulate the termination of mitochondrial transcription, influencing mitochondrial genome expression and maintenance. Mutations or alterations in MTERF2 have been associated with specific congenital anomalies and modulate susceptibility to aminoglycoside-induced deafness, but it is not a conventional therapeutic target or drug receptor[1][2][3][7].

Other names

Transcription termination factor 2, mitochondrialMTERF2MTERFD3mTERF2mTERF-likemTERFLFLJ14062mitochondrial transcription termination factor-like proteinmTERF domain-containing protein 3, mitochondrialtranscription termination factor 2, mitochondrialMTERF domain containing 3