Mitochondrial Uncoupling Protein (UCP)

Mitochondrial uncoupling proteins (UCPs) are a family of transporters located in the inner mitochondrial membrane that mediate a regulated discharge of the proton gradient generated by the respiratory chain, effectively uncoupling oxidative phosphorylation from ATP synthesis. This process dissipates energy as heat rather than storing it as ATP, and serves several physiological roles including thermogenesis, regulation of redox balance, and reduction in reactive oxygen species (ROS) production.

Other names

UCP1UCP2UCP3UCP4UCP5SLC25A7SLC25A8SLC25A9SLC25A27SLC25A14BMCP1

Proton leak across the inner mitochondrial membrane, dissipating the proton gradient and generating heat instead of ATP.