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MT-ATP6 pseudogene 25 (MTATP6P25) is a nuclear-encoded non-functional genomic sequence that resembles the mitochondrial gene MT-ATP6. Unlike the functional mitochondrial gene MT-ATP6, which codes for a key subunit ("a" subunit) of the F_o complex of mitochondrial ATP synthase (Complex V) and plays an essential role in ATP production and cellular energy metabolism[1][3][5][7][8][9], MTATP6P25 does not code for any protein or contribute to mitochondrial function. There is no evidence in the scientific or clinical literature that MTATP6P25 is expressed, functional, or plays a role in human physiology or disease. Pseudogenes such as this often arise from duplication or retrotransposition events and are typically transcriptionally inactive.
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