Mitochondrially encoded cytochrome c oxidase I pseudogene 25 (MTCO1P25)

Mitochondrially encoded cytochrome c oxidase I pseudogene 25 (MTCO1P25) is a human pseudogene, meaning it is a nonfunctional segment of DNA derived from the MT-CO1 gene, which encodes the key catalytic subunit of the enzyme cytochrome c oxidase (complex IV of the mitochondrial respiratory chain)[4]. Pseudogenes such as MTCO1P25 do not encode functional proteins and are not considered therapeutic drug targets, receptors, or enzymes. No direct biological functions, disease associations, drug interactions, or therapeutic mechanisms are reported for this locus. The functional parent gene, MT-CO1, is critical in oxidative phosphorylation and has relevance in diseases such as mitochondrial disorders and cancer, but these roles do not extend to its pseudogenes[1][2][4]. Is there something wrong with this target? Yes. MTCO1P25 refers to a pseudogene, not a functional protein or biologically active receptor or enzyme. It is not considered a therapeutic target[4]. If your interest is in the biologically active protein encoded by the mitochondrial DNA (MT-CO1), you should refer instead to “Mitochondrially encoded cytochrome c oxidase I (MT-CO1, COX1)”[1][2]. Summary: MTCO1P25 is a pseudogene without known biological function, disease role, or therapeutic relevance. It should not be conflated with the functional mitochondrial-encoded cytochrome c oxidase I, which is a crucial component of cell respiration and does play important biological and pathological roles[4].

Other names

MT-CO1 pseudogene 25MTCO1P25