Mitochondrially encoded cytochrome c oxidase II pseudogene

Mitochondrially encoded cytochrome c oxidase II pseudogenes are DNA sequences derived from the functional mitochondrial gene MT-CO2, which encodes cytochrome c oxidase subunit II, a core enzyme involved in mitochondrial electron transport and ATP generation. This pseudogene, present in the nuclear genome, no longer encodes a functional protein, having lost its protein-coding ability due to disabling mutations such as frameshifts or premature stop codons. While most pseudogenes are nonfunctional genomic relics, certain pseudogenes in general can at times have regulatory effects (for instance, through RNA-mediated mechanisms), but there is no direct evidence suggesting functional or disease relevance for this particular pseudogene. Pseudogenes are not therapeutic targets, and this entry appears either as a misannotation or a biologically non-functional sequence differentiated from the functional MT-CO2 gene, which is involved in the electron transport chain.

Other names

MTCO2PMT-CO2 pseudogeneMTCO2P12 (similar/modeled pseudogenes)