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MT-CO3 pseudogene 45 (MTCO3P45) is a non-functional genomic sequence derived from the mitochondrial MT-CO3 gene, which encodes cytochrome c oxidase subunit III. Unlike the functional MT-CO3 gene—which is a subunit of the mitochondrial respiratory chain enzyme cytochrome c oxidase involved in oxidative phosphorylation and is associated with multiple mitochondrial disorders—MTCO3P45 does not encode a protein and has no demonstrated biological activity or significance as a therapeutic target[3].
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