Mitochondrially encoded cytochrome c oxidase pseudogene

Mitochondrially encoded cytochrome c oxidase pseudogene (ENSG00000242152) refers to an inactive genetic sequence that resembles genes encoding subunits of cytochrome c oxidase, the final enzyme in the mitochondrial respiratory chain. Cytochrome c oxidase subunit pseudogenes do not code for functional proteins; they have been inactivated by mutation. Such pseudogenes are present in the human genome, reflecting evolutionary processes, and have no role in mitochondrial function or human disease except as rare elements of genetic regulation in specific contexts. Pseudogenes such as ENSG00000242152 should not be mistaken for functional subunits of the cytochrome c oxidase complex (like COX4I1 or COX8B, which are functional proteins involved in electron transport). Drugs and disease associations relate to true functional enzymes, not their pseudogenes. Gene database entries (GeneCards, Ensembl, etc.) catalog such pseudogenes primarily for completeness of genome annotation, not as therapeutic or diagnostic targets.

Other names

COX8BP pseudogeneMT-CO2 pseudogenecytochrome c oxidase subunit pseudogeneprocessed pseudogene