Mitochondrially encoded NADH dehydrogenase 1 pseudogene

Mitochondrially encoded NADH dehydrogenase 1 pseudogene (ENSG00000287800) is a non-functional genomic element derived from the **MT-ND1** gene, which encodes a core subunit of mitochondrial complex I, the NADH:ubiquinone oxidoreductase responsible for catalyzing electron transfer from NADH to ubiquinone in the respiratory chain[1][6]. Pseudogenes like ENSG00000287800 do not code for functional proteins; instead, they may contribute to regulation of their parental gene through mechanisms such as non-coding RNA transcription, epigenetic modification, or gene expression modulation, but do not play a canonical role in mitochondrial electron transport or human disease directly[3][4]. Their presence is sometimes relevant in genomic studies or as regulatory elements, but ENSG00000287800 is not a therapeutic, diagnostic, or molecular target in a conventional sense[1][3]. Key points: - This gene is a **pseudogene** of MT-ND1, not the functionally active (protein-coding) gene. - It is **not a therapeutic target** and should not be confused with NADH dehydrogenase 1 itself, which is a bona fide enzyme and sometimes a disease biomarker[6]. - It may have roles in the **epigenetic regulation** or non-coding RNA biology but not in direct drug targeting[3]. Please note: For information on the actual mitochondrial NADH dehydrogenase 1 (MT-ND1), refer to ENSG00000198888, not ENSG00000287800[6].

Other names

MT-ND1 pseudogeneND1 pseudogene