Mitochondrially encoded NADH dehydrogenase 5 pseudogene

This entry refers to a pseudogene homologous to the mitochondrially encoded NADH dehydrogenase 5 (MT-ND5) gene. Pseudogenes are nonfunctional sequences similar to known genes but typically contain mutations or deletions preventing expression of a functional protein. MT-ND5, the original functional gene, encodes an essential subunit of Complex I (NADH:ubiquinone oxidoreductase) in the mitochondrial electron transport chain, which is vital for ATP synthesis in cells[1][7]. However, the pseudogene variant (as represented by ENSG00000283130) does not produce a functional protein, is not involved in electron transport or cellular respiration, and is not considered a biological target for drugs or therapeutic intervention. Clarification: This target is not a receptor, enzyme, transporter, or other actionable biological molecule; it is a non-functional pseudogene. Structured data collection for genes intended for therapeutic targeting should exclude pseudogenes unless specifically studying regulatory non-coding elements or evolutionary genomics[1][7].

Other names

MT-ND5 pseudogeneNADH dehydrogenase 5 pseudogeneND5 pseudogene