Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 pseudogene 21 (MTND2P21)

MT-ND2 pseudogene 21 (MTND2P21) refers to a pseudogene related to the mitochondrial gene MT-ND2, which encodes a core subunit of mitochondrial respiratory Complex I, involved in NADH dehydrogenase (ubiquinone) activity and electron transport[1][2]. However, as a pseudogene, MTND2P21 does not code for a functional protein and is not known to be transcribed or translated into an active enzyme[5]. While the parental gene, MT-ND2, is required for mitochondrial oxidative phosphorylation and is implicated in several mitochondrial and neurodegenerative diseases, pseudogenes like MTND2P21 generally have no direct molecular function and are not considered therapeutic targets or biomarkers[3][5]. Some studies enumerate MTND2-related pseudogenes among differentially expressed elements in tissues in studies of mitochondrial dysfunction, but there is no evidence that MTND2P21 itself is directly functional, targetable, or disease-causative[3]. Pseudogenes can sometimes play regulatory roles at the RNA level, but such a role for MTND2P21 has not been established or described in the scientific literature to date[3]. Note: - The parental gene, MT-ND2, is a protein-coding mitochondrial gene essential for cell energy metabolism and is a recognized disease gene[1][2]. - MTND2P21 is a nuclear-encoded sequence derived from MT-ND2, but as a pseudogene, it is non-functional[5]. - There is no evidence that MTND2P21 is a therapeutic target, receptor, enzyme, transporter, or has direct disease associations. - is_incorrect is set to true, as this is not a true target (not functional, not druggable, does not fit the requested receptor/enzyme classifications), and it may be mistaken for its protein-coding parental gene.

Other names

MT-ND2 pseudogene 21MTND2P21Mitochondrially encoded NADH dehydrogenase 2 pseudogene 21Pseudogene of MT-ND2 subunit

None