Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 pseudogene 5 (MTND3P5)

MT-ND3 pseudogene 5 (MTND3P5) is a non-coding pseudogene sequence similar to the mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 (MT-ND3) gene. Unlike the MT-ND3 gene, which encodes a subunit of Complex I in the mitochondrial electron transport chain and is implicated in mitochondrial disorders such as Leigh syndrome and Leber hereditary optic neuropathy, the pseudogene does not produce a functional protein and has not been demonstrated to have biological function, disease association, or relevance as a therapeutic target. Current literature has only recently begun to profile expression of some mitochondrial pseudogenes in the context of large-scale transcriptomics or neurodegenerative disease [4]. There is no evidence MTND3P5 is a functional receptor, enzyme, transporter, or drug target. All known molecular functions, clinical significance, and druggability relate to the functional MT-ND3 protein-coding gene, not to its pseudogene relatives such as MTND3P5[1][3][2][4]. Currently, MTND3P5 should not be considered a therapeutic or biomedical target.

Other names

MTND3P5MT-ND3 pseudogene 5Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 pseudogene 5

None