Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitochondrially encoded transfer RNA glutamine (MT-TQ)
- Target
- MT-TQ
- Molecular classification
- Transfer RNA (tRNA), Non-coding RNA gene, Mitochondrial genome component
01
Overview
Mitochondrially encoded transfer RNA glutamine (MT-TQ, trnQ) is one of the 22 tRNA genes found in human mitochondrial DNA, specifically responsible for encoding the tRNA that transfers glutamine during the translation of mitochondrial messenger RNAs. Proper function of MT-TQ is critical for mitochondrial protein synthesis, as these proteins participate in the oxidative phosphorylation process that produces cellular ATP. Mutations in MT-TQ can impair mitochondrial translation and are associated with a range of mitochondrial diseases, including hypertrophic cardiomyopathy and neuromuscular disorders. MT-TQ itself is not a direct therapeutic target, but its genetic integrity is essential for normal cell function.
- Other names
- trnQtRNA-Glnmitochondrial tRNA-GlnMT-TQtRNA-Glutamine
02
Mechanism of action
None known. There are no approved drugs acting by directly targeting MT-TQ.
03
Biological functions
Mitochondrial protein biosynthesis (translation of mitochondrially encoded proteins)Amino acid (glutamine) transport to mitochondrial ribosome for peptide elongationMaintenance of mitochondrial respiratory function
04
Disease associations
Cardiomyopathies, including hypertrophic cardiomyopathyNeuromuscular disordersMitochondrial cytopathiesOther mitochondrial disorders
05
Safety considerations
Therapeutic targeting of mitochondrial tRNA genes (such as via gene editing or replacement therapy) is experimentally challenging due to risks of disrupting essential mitochondrial protein synthesis and inducing widespread cellular dysfunction
06
Biomarkers
Pathogenic variants in MT-TQ may serve as biomarkers for mitochondrial diseases, especially cardiomyopathies and neuromuscular disorders
Beyond the preview
Go deeper on Mitochondrially encoded transfer RNA glutamine (MT-TQ).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitochondrially encoded transfer RNA glutamine (MT-TQ).