Mitochondrially encoded tRNA aspartic acid (MT-TD)

Mitochondrially encoded tRNA aspartic acid (MT-TD, also known as trnD) is a tRNA molecule transcribed from the mitochondrial genome. Its primary role is to attach to aspartic acid and deliver it for protein synthesis within mitochondria. Like other mitochondrial tRNAs, MT-TD is critical for accurate translation of the 13 mitochondrially encoded proteins essential for the respiratory chain. Pathogenic mutations in MT-TD may compromise its structure, stability, or aminoacylation, leading to defective mitochondrial protein synthesis and disease phenotypes such as deafness and multisystem mitochondrial disorders[3][1][4]. No drugs currently target this RNA directly, but its mutation status can inform mitochondrial disease diagnosis and categorization[3][1][4].

Other names

trnDtRNA-AsptRNAAspMTTD

Not applicable. Potential interventions would be experimental and aimed at correcting the effects of pathogenic mutations (e.g., genetic therapies), not standard small-molecule mechanisms.