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Mitochondrially encoded tRNA histidine (MT-TH)
- Target
- MT-TH
- Molecular classification
- Other (mitochondrial transfer RNA)
01
Overview
Mitochondrially encoded tRNA histidine (MT-TH) is a transfer RNA located on the mitochondrial genome, responsible for transporting the amino acid histidine to the growing polypeptide chain during protein synthesis within mitochondria[3][1]. It consists of a small, 69-nucleotide RNA that contributes to the assembly of mitochondrial proteins, especially those involved in oxidative phosphorylation. Mutations in MT-TH can disrupt mitochondrial protein synthesis and are associated with several mitochondrial diseases, but MT-TH itself is not a receptor, enzyme, or drug target in the classic sense[1][3][6].
- Other names
- MTTHtrnHtRNA^His^tRNA-His
02
Biological functions
Protein translation (mitochondrial translation)Mitochondrial gene expressionAminoacylation (histidine transfer)
03
Disease associations
Mitochondrial disease (including myopathy, mitochondrial encephalopathy, lactic acidosis, stroke-like episodes; known as MELAS syndrome and others)
04
Biomarkers
Mutations in MT-TH as biomarkers for mitochondrial disorders
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