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Target intelligence / Profile preview
Mitogen‑activated protein kinase‑interacting serine/threonine-protein kinase 1 (MNK1)
- Target
- MNK1
- Molecular classification
- Enzyme, Serine/Threonine Kinase, MAPK-related kinase
01
Overview
MNK1 is a serine/threonine protein kinase that interacts with and is activated by the mitogen-activated protein kinases ERK1 and p38. It plays a key role in cellular signaling pathways, particularly those involved in the response to growth factors, stress stimuli, and cytokines. It regulates mRNA translation by phosphorylating eIF4E, modulates cytokine production in T cells, and demonstrates a protective role against cardiac remodeling.
- Other names
- MKNK1
02
Mechanism of action
MNK1 inhibitors block eIF4E phosphorylation, thereby inhibiting cap-dependent translation.
03
Biological functions
Regulation of mRNA translationImmune response modulationRegulation of translationSignal transductionCell proliferationCell survivalCardiac protection
04
Disease associations
CancerInflammationCardiovascular disease
05
Safety considerations
Potential for off-target effects due to the kinase's involvement in multiple signaling pathways.
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