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Target intelligence / Profile preview
Mitogen-activated protein kinase (MAPK)
- Target
- MAPK
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine-specific protein kinase
01
Overview
Mitogen-activated protein kinases (MAPKs) are a family of serine/threonine-specific protein kinases that play a central role in transducing extracellular signals into various intracellular responses. They are key regulators of essential cellular processes, including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. MAPKs are activated by a wide range of stimuli and function within highly conserved signaling modules known as MAPK cascades or pathways. These kinases are regulated by phosphorylation and dephosphorylation events. Major subfamilies include ERKs, JNKs, and p38 isoforms. MAPKs are evolutionarily conserved and regulate diverse cellular programs.
- Other names
- ERKs (extracellular signal-regulated kinases)JNKs (c-Jun N-terminal kinases)p38 isoformsMAP KinaseMAP2KMEKMAP3K
02
Mechanism of action
Inhibition of kinase activity; Modulation of phosphorylation
03
Biological functions
Cell proliferationDifferentiationApoptosisStress responseGene expressionMitosisCell survivalSignal transduction
04
Disease associations
CancerInflammationNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Off-target effects due to kinase family similaritiesPotential for drug resistance development
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