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Target intelligence / Profile preview
Mitogen-activated protein kinase–activated protein kinase 5 (MAPKAPK5)
- Target
- MAPKAPK5
- Molecular classification
- Enzyme, Serine/threonine-protein kinase, MAPKAP kinase
01
Overview
Mitogen-activated protein kinase–activated protein kinase 5 (MAPKAPK5), also known as PRAK, is a serine/threonine-protein kinase and a member of the MAPKAP kinase subfamily. It acts as a tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. It is activated by cellular stress and proinflammatory cytokines and phosphorylates several substrates including heat shock protein HSP27, FOXO3, ERK3/MAPK6, and ERK4/MAPK4. It plays roles in cellular stress response pathways and regulation of cell motility. Loss or reduced activity may contribute to cancer progression, and reduced levels have been linked with Alzheimer's disease.
- Other names
- PRAKMitogen‑activated protein kinase–activated protein kinase V
02
Biological functions
Regulation of cell motilityCellular stress responsemTORC1 signalingGene expression/transcriptionTP53 activity regulationPhosphorylation of HSP27Phosphorylation of FOXO3Phosphorylation of ERK3/MAPK6Phosphorylation of ERK4/MAPK4
03
Disease associations
CancerNeurodegenerative diseaseNeurocardiofaciodigital syndromePulmonary immaturity
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