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Target intelligence / Profile preview
Mitogen-Activated Protein Kinase 1 (ERK2)
- Target
- ERK2
- Molecular classification
- Enzyme, Protein Kinase, MAP Kinase, Serine/Threonine Kinase
01
Overview
Mitogen-activated protein kinase 1 (MAPK1), commonly known as ERK2, is a serine/threonine protein kinase that plays a central role in the MAP kinase signaling pathway. ERK2 acts as an integration point for multiple biochemical signals and regulates diverse cellular processes including proliferation, differentiation, transcription regulation, development, cell cycle progression, migration, survival, metabolism, and apoptosis. It is activated by MEKs via dual phosphorylation and phosphorylates substrates containing Pro-Xaa-(Ser/Thr)-Pro sequences. Dysregulation of ERK2 is implicated in cancer, making it a target for anti-tumor drug development.
- Other names
- Extracellular signal-regulated kinase 2p42-MAPKMAPK1
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Signal transductionCell proliferationCell differentiationTranscription regulationDevelopmentCell cycle progressionCell migrationCell survivalMetabolismApoptosisGene expression
04
Disease associations
Cancer
05
Safety considerations
On-target toxicitiesResistance mechanisms
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